Hox gene regulation in embryos and pseudo-embryos

Abstract: During vertebrate development, clustered Hox genes are activated in a precise time-sequence, leading to patterns necessary to properly establish the body plan. The mechanism underlying this in cis timing phenomenon has remained unknown ever since its observation in 1989, due to the difficulty to approach it using early gastrulating mouse embryos. I will discuss an alternative possibility, which is to use pseudo-embryos produced out of ES cells (referred to as gastruloids) to address this now 30 years old question and will show some preliminary data indicating that this system may allow us to more efficiently tackle this issue in the next few years to come.

biochemistrycancer biologychemical biologycell biologydevelopmental biologydrug discoveryevolutiongeneticsimmunologymolecular biologymicrobiologyneuroscienceplant sciencessystems biologybiotechnologybiological techniquesbiophysics

Audience: researchers in the discipline

( video )

Comments: Organizers can be contacted at m.tariq@lums.edu.pk or 22100032@lums.edu.pk for the zoom link.

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Colloquium zooming Molecular & Cellular Biology LUMS

Series comments: Zooming Molecular & Cellular Biology Colloquium was initiated on July 28th, 2020 by the Biology department at Syed Babar Ali School of Science & Engineering (SBASSE), Lahore University of Management Sciences (LUMS). The series follows through various topics which come under the ambit of Molecular and Cellular Biology and we’ve had the pleasure and honor of hosting some of the most knowledgeable scientists from around the globe. Organizers can be reached out at 24100162@lums.edu.pk or 24100001@lums.edu.pk for the Zoom link of individual talks. All lectures are LIVE streamed on SBASSE's official Facebook page.

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